Ontology highlight
ABSTRACT:
SUBMITTER: Giner-Delgado C
PROVIDER: S-EPMC6748972 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Giner-Delgado Carla C Villatoro Sergi S Lerga-Jaso Jon J Gayà-Vidal Magdalena M Oliva Meritxell M Castellano David D Pantano Lorena L Bitarello Bárbara D BD Izquierdo David D Noguera Isaac I Olalde Iñigo I Delprat Alejandra A Blancher Antoine A Lalueza-Fox Carles C Esko Tõnu T O'Reilly Paul F PF Andrés Aida M AM Ferretti Luca L Puig Marta M Cáceres Mario M
Nature communications 20190917 1
Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. Here, we develop a new high-throughput genotyping method based on probe hybridization and amplification, and we perform a complete study of 45 common human inversions of 0.1-415 kb. Most inversions promoted by homologous recombination occur re ...[more]