Ontology highlight
ABSTRACT:
SUBMITTER: Kumari R
PROVIDER: S-EPMC6751159 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kumari Rajni R Deshmukh Ruhi S RS Das Sanjeev S
Nature communications 20190918 1
Caspase-10 belongs to the class of initiator caspases and is a close homolog of caspase-8. However, the lack of caspase-10 in mice and limited substrate repertoire restricts the understanding of its physiological functions. Here, we report that ATP-citrate lyase (ACLY) is a caspase-10 substrate. Caspase-10 cleaves ACLY at the conserved Asp1026 site under conditions of altered metabolic homeostasis. Cleavage of ACLY abrogates its enzymatic activity and suppresses the generation of acetyl-CoA, whi ...[more]