Ontology highlight
ABSTRACT:
SUBMITTER: Kriegs M
PROVIDER: S-EPMC6753061 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kriegs Malte M Clauditz Till Sebastian TS Hoffer Konstantin K Bartels Joanna J Buhs Sophia S Gerull Helwe H Zech Henrike Barbara HB Bußmann Lara L Struve Nina N Rieckmann Thorsten T Petersen Cordula C Betz Christian Stephan CS Rothkamm Kai K Nollau Peter P Münscher Adrian A
Scientific reports 20190919 1
Overexpression of the epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas (HNSCC) is considered to cause increased EGFR activity, which adds to tumorigenicity and therapy resistance. Since it is still unclear, whether EGFR expression is indeed associated with increased activity in HNSCC, we analyzed the relationship between EGFR expression and auto-phosphorylation as a surrogate marker for activity. We used a tissue micro array, fresh frozen HNSCC tumor and correspo ...[more]