Ontology highlight
ABSTRACT:
SUBMITTER: Singla A
PROVIDER: S-EPMC6753146 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190919 1
Protein recycling through the endolysosomal system relies on molecular assemblies that interact with cargo proteins, membranes, and effector molecules. Among them, the COMMD/CCDC22/CCDC93 (CCC) complex plays a critical role in recycling events. While CCC is closely associated with retriever, a cargo recognition complex, its mechanism of action remains unexplained. Herein we show that CCC and retriever are closely linked through sharing a common subunit (VPS35L), yet the integrity of CCC, but not ...[more]