Dataset Information

Contagion models for the transmission of drug abuse among propinquity-of-rearing defined acquaintances: A Swedish national study.

ABSTRACT: BACKGROUND:Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? METHODS:PRDAs were defined as pairs of same-age males born 1975-1990 who grew up within 2?km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent risk for DA first registration in a second PRDA (PRDA2) within 3 years of PRDA1's registration. RESULTS:In 181,743 PRDA pairs, the best-fit model, controlling for age and PRDA2 community risk, included 2 slopes of proximity-risk relationships in childhood and three in adulthood. Risk for DA in PRDA2 was strongly predicted by childhood proximity to PRDA1: 0 to 0.5?km - Hazard ratio (HR) per kilometer 0.52 and 0.6-2 km 0.78. HRs for PRDA2 as a function of adult proximity to PRDA1 were: 0-1 km 0.887, 1-75 km 0.996 and >75?km 0.9997. Proximity-dependent PRDA2 risk was moderated by age, familial risk and educational attainment, attenuated by increasing PRDA1-PRDA2 age differences and stronger for older to younger versus younger to older pairs. CONCLUSIONS:Transmission of DA risk between acquaintances growing up together was attenuated by increasing distance in adulthood. Strength of the acquaintance, indexed by childhood propinquity and age difference, modified transmission strength. The impact of adult proximity on transmission was reduced in acquaintances with higher resistance to DA due to older age, higher educational attainment or lower familial risk. Our results support the validity of DA contagion models.

SUBMITTER: Kendler KS

PROVIDER: S-EPMC6754117 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Contagion models for the transmission of drug abuse among propinquity-of-rearing defined acquaintances: A Swedish national study.

Kendler Kenneth S KS Ohlsson Henrik H Sundquist Jan J Sundquist Kristina K

Drug and alcohol dependence 20190604

<h4>Background</h4>Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)?<h4>Methods</h4>PRDAs were defined as pairs of same-age males born 1975-1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent risk for DA first registration in a second PRDA (PRDA2) within 3 years of PRDA1's regis ...[more]

PMID: 31203149

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Project description:Using Swedish nationwide registry data, the authors investigated genetic and environmental risk factors in the etiology of drug abuse by twin sibling modeling. The authors followed up with epidemiological analyses to identify shared environmental influences on drug abuse.Drug abuse was defined using public medical, legal, or pharmacy records. Twin and sibling pairs were obtained from the national twin and genealogical registers. Information about sibling pair residence within the same household, small residential area, or municipality was obtained from Statistics Sweden. The authors predicted concordance for drug abuse by years of co-residence until the older sibling turned 21 and risk for future drug abuse in adolescents living with parental figures as a function of family-level socioeconomic status and neighborhood social deprivation.The best twin sibling fit model predicted substantial heritability for drug abuse in males (55%) and females (73%), with environmental factors shared by siblings operating only in males and accounting for 23% of the variance in liability. For each year of living in the same household, the probability of sibling concordance for drug abuse increased 2%-5%. When not residing in the same household, concordance was predicted from residence in the same small residential area or municipality. Risk for drug abuse was predicted both by family socioeconomic status and neighborhood social deprivation. Controlling for family socioeconomic status, each year of living in a high social deprivation neighborhood increased the risk for drug abuse by 2%.Using objective registry data, the authors found that drug abuse is highly heritable. A substantial proportion of the shared environmental effect on drug abuse comes from community-wide rather than household-level influences. Genetic effects demonstrated in twin studies have led to molecular analyses to elucidate biological pathways. In a parallel manner, environmental effects can be followed up by epidemiological studies to clarify social mechanisms.

Dataset Information

Contagion models for the transmission of drug abuse among propinquity-of-rearing defined acquaintances: A Swedish national study.

Publications

Contagion models for the transmission of drug abuse among propinquity-of-rearing defined acquaintances: A Swedish national study.

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