Ontology highlight
ABSTRACT:
SUBMITTER: Lelyveld VS
PROVIDER: S-EPMC6755091 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lelyveld Victor S VS O'Flaherty Derek K DK Zhou Lijun L Izgu Enver Cagri EC Szostak Jack W JW
Nucleic acids research 20190901 17
Genetic polymers that could plausibly govern life in the universe might inhabit a broad swath of chemical space. A subset of these genetic systems can exchange information with RNA and DNA and could therefore form the basis for model protocells in the laboratory. N3'→P5' phosphoramidate (NP) DNA is defined by a conservative linkage substitution and has shown promise as a protocellular genetic material, but much remains unknown about its functionality and fidelity due to limited enzymatic tools. ...[more]