Ontology highlight
ABSTRACT:
SUBMITTER: Wong LE
PROVIDER: S-EPMC3384315 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wong Leo E LE Li Yan Y Pillay Shubhadra S Frolova Ludmila L Pervushin Konstantin K
Nucleic acids research 20120301 12
Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution structures of the wild-type N-domain of human eRF1 exhibited omnipotent specificity, i.e. recognition of all three stop codons, and its unipotent mutant with UGA-only specificity, we found the conserved GTS loo ...[more]