Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC6756076 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhang Chi C Stockwell Simon R SR Elbanna May M Ketteler Robin R Freeman Jamie J Al-Lazikani Bissan B Eccles Suzanne S De Haven Brandon Alexis A Raynaud Florence F Hayes Angela A Clarke Paul A PA Workman Paul P Mittnacht Sibylle S
Oncogene 20190712 30
Deregulation of cyclin-dependent kinases 4 and 6 (CDK4/6) is highly prevalent in cancer; yet, inhibitors against these kinases are currently used only in restricted tumour contexts. The extent to which cancers depend on CDK4/6 and the mechanisms that may undermine such dependency are poorly understood. Here, we report that signalling engaging the MET proto-oncogene receptor tyrosine kinase/focal adhesion kinase (FAK) axis leads to CDK4/6-independent CDK2 activation, involving as critical mechani ...[more]