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A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions.

ABSTRACT: A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important bis-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphenoxy) acetic acid and 2-aminobenzamide as bifunctional reagents and an isocyanide without using any catalyst, with excellent overall yields.

SUBMITTER: Shaabani S 

PROVIDER: S-EPMC6759581 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A One-Pot Synthesis of Oxazepine-Quinazolinone bis-Heterocyclic Scaffolds via Isocyanide-Based Three-Component Reactions.

Shaabani Shabnam S   Shaabani Ahmad A   Kucerakova Monika M   Dusek Michal M  

Frontiers in chemistry 20190918

A novel, efficient and environmentally friendly approach has been developed for the synthesis of biologically important <i>bis</i>-heterocyclic oxazepine-quinazolinone derivatives. The structurally interesting compounds of high purity were synthesized by a one-pot three-component reaction of 2-(2-formylphenoxy) acetic acid and 2-aminobenzamide as bifunctional reagents and an isocyanide without using any catalyst, with excellent overall yields. ...[more]

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