Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity.
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ABSTRACT:
SUBMITTER: Di Costanzo A
PROVIDER: S-EPMC6760560 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity.
Di Costanzo Alessia A Pacifico Lucia L Chiesa Claudio C Perla Francesco Massimo FM Ceci Fabrizio F Angeloni Antonio A D'Erasmo Laura L Di Martino Michele M Arca Marcello M
Pediatric research 20190123 5
<h4>Objectives</h4>To comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children.<h4>Methods</h4>Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3, TM6SF2, GCKR, and MBOAT7 gene variants. Percentage hepatic fat content (HFF%) was measured by nuclear magnetic resonance.<h4>Results</h4>HFF% was positively related with BMI, HOMA<sub>IR</sub>, metabolic syndrome, ALT, AST, γGT, a ...[more]
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