Ontology highlight
ABSTRACT:
SUBMITTER: Kaboudin B
PROVIDER: S-EPMC6761612 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
ACS omega 20190910 13
A practical and efficient method has been developed for the preparation of optically active α-hydroxyphosphonates through resolution of the racemates. Treatment of racemic diethyl 1-hydroxy-1-phenylmethylphosphonate (<b>1)</b> with (+)-dibenzoyl-L-tartaric anhydride gave two diastereomeric esters <b>2</b> and <b>3</b> in the presence of bismuth triflate (15 mol %) in an 86:14 ratio. The two diastereomeric esters were separated by simple column chromatography, and the structure for the major dias ...[more]