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Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae.

ABSTRACT: Herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent and relatively neuroinvasive in animal models compared with other wild-type HSV-1 strains. To identify the genetic determinants that lead to the unique phenotypes of the McKrae strain, we sequenced its genome with PacBio single-molecule real-time (SMRT) technology and resolved the complete sequence.

SUBMITTER: Jiao X

PROVIDER: S-EPMC6763650 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae.

Jiao Xiaoli X Sui Hongyan H Lyons Christopher C Tran Bao B Sherman Brad T BT Imamichi Tomozumi T

Microbiology resource announcements 20190926 39

Herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent and relatively neuroinvasive in animal models compared with other wild-type HSV-1 strains. To identify the genetic determinants that lead to the unique phenotypes of the McKrae strain, we sequenced its genome with PacBio single-molecule real-time (SMRT) technology and resolved the complete sequence. ...[more]

PMID: 31558635

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