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Genome sequence of herpes simplex virus 1 strain McKrae.

ABSTRACT: The herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent compared to other wild-type strains of HSV-1. To help us better understand the genetic determinants that lead to differences in the pathogenicity of McKrae and other HSV-1 strains, we sequenced its genome. Comparing the sequence of McKrae's genome to that of strain 17 revealed that the genomes differ by at least 752 single nucleotide polymorphisms (SNPs) and 86 insertion/deletion events (indels). Although the majority of these polymorphisms reside in noncoding regions, 241 SNPs and 10 indels alter the protein-coding sequences of 58 open reading frames. Some of these variations are expected to contribute to the pathogenic phenotype of McKrae.

SUBMITTER: Macdonald SJ

PROVIDER: S-EPMC3416131 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Genome sequence of herpes simplex virus 1 strain McKrae.

Macdonald Stuart J SJ Mostafa Heba H HH Morrison Lynda A LA Davido David J DJ

Journal of virology 20120901 17

The herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent compared to other wild-type strains of HSV-1. To help us better understand the genetic determinants that lead to differences in the pathogenicity of McKrae and other HSV-1 strains, we sequenced its genome. Comparing the sequence of McKrae's genome to that of strain 17 revealed that the genomes differ by at least 752 single nucleotide polymorphisms (SNPs) and 86 insertion/deletion events (indels). Although the majority of these p ...[more]

PMID: 22879612

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