Dataset Information

A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia.

ABSTRACT:

Background

Equine dysautonomia (ED) causes degeneration and loss of autonomic neurons. Approximately 50% of chronic cases recover, but it is unclear how they survive neuronal loss.

Objectives

To assess lesions, autonomic neuron numbers, interstitial cells of Cajal (ICC), and neurodegeneration in recovered cases.

Animals

Thirteen cases (group ED), euthanized 10.3?±?5.2 (1-16) years from diagnosis and 6 age-matched controls (group C).

Methods

Prospective, case control; routine post mortem examination, neuron counts in peripheral and enteric ganglia and immunohistochemical assessment of neural networks (Protein gene product [PGP] 9.5), ICC (c-kit), and neurodegeneration (beta-amyloid precursor protein and ubiquitin) in intestine.

Results

Postmortem findings in group ED were small intestinal dilation (4/12, 33%) and muscular hypertrophy (4/12, 33%), and gastric mucosal hypertrophy (3/11, 27%) and ulceration (4/11, 36%). Neuron density was lower in group ED (mean 39% lower for cranial cervical ganglion [P Conclusions and clinical importanceIntact ICC in muscularis externa might help maintain motility after neuronal loss. Treatment supporting ICC function warrants investigation.

SUBMITTER: Milne EM

PROVIDER: S-EPMC6766533 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia.

Milne Elspeth M EM Pirie R Scott RS Hahn Caroline N CN Del-Pozo Jorge J Drummond Dawn D Moss Sharon S McGorum Bruce C BC

Journal of veterinary internal medicine 20190722 5

<h4>Background</h4>Equine dysautonomia (ED) causes degeneration and loss of autonomic neurons. Approximately 50% of chronic cases recover, but it is unclear how they survive neuronal loss.<h4>Objectives</h4>To assess lesions, autonomic neuron numbers, interstitial cells of Cajal (ICC), and neurodegeneration in recovered cases.<h4>Animals</h4>Thirteen cases (group ED), euthanized 10.3 ± 5.2 (1-16) years from diagnosis and 6 age-matched controls (group C).<h4>Methods</h4>Prospective, case control; ...[more]

PMID: 31332854

Similar Datasets

Project description:BACKGROUND:Variation in equine caudal cervical spine morphology at C6 and C7 has high prevalence in Warmblood horses and is suspected to be associated with pain in a large mixed-breed group of horses. At present no data exist on the relationship between radiographic phenotype and clinical presentation in Warmblood horses in a case-control study. OBJECTIVES:To establish the frequency of radiographically visible morphologic variation in a large group of Warmblood horses with clinical signs and compare this with a group without clinical signs. We hypothesised that occurrence of morphologic variation in the case group would not differ from the control group, indicating there is no association between clinical signs and morphologic variation. STUDY DESIGN:Retrospective case-control. METHODS:Radiographic presence or absence of morphologic variation of cervical vertebrae C6 and C7 was recorded in case (n = 245) and control horses (n = 132). Case and control groups were compared by univariable Pearson's Chi-square and multivariable logistic regression for measurement variables age, sex, breed, degenerative joint disease and morphologic variation at C6 and C7. Odds ratio and confidence intervals were obtained. A P?0.05 was considered statistically significant. RESULTS:Morphologic variation at C6 and C7 (n = 108/377 = 28.6%; Cases 58/245 = 23.7%; Control 50/132 = 38%) was less frequent in horses with clinical signs in univariable testing (OR 0.48, 95% CI 0.3-0.8, P = 0.001). Age, sex, breed and degenerative joint disease were not retained in the final multivariable logistic regression step whereas morphologic variation remained significantly less present in horses with clinical signs. MAIN LIMITATIONS:Possible demographic differences between equine clinics. CONCLUSIONS:Morphologic variation in the caudal cervical spine was detected more frequently in horses without clinical signs. Therefore, radiographic presence of such variation does not necessarily implicate the presence of clinical signs.

Dataset Information

A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia.

Background

Objectives

Animals

Methods

Results

Publications

A study of residual lesions in horses that recovered from clinical signs of chronic equine dysautonomia.

Similar Datasets

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