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Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure.

ABSTRACT: A one-pot three-component tandem reaction involving a key Pictet-Spengler-like annulation step has been developed, providing an efficient method for the synthesis of 3,4-dihydroquinazolines in moderate to good yields from amides, aldehydes, and amines. The multicomponent triflic anhydride mediated reaction tolerates the installation of numerous functional groups, affording extensive diversity about the heterocyclic scaffold.

SUBMITTER: Magyar CL

PROVIDER: S-EPMC6767623 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure.

Magyar Christina L CL Wall Tyler J TJ Davies Steven B SB Campbell Molly V MV Barna Haven A HA Smith Sydney R SR Savich Christopher J CJ Mosey R Adam RA

Organic & biomolecular chemistry 20190801 34

A one-pot three-component tandem reaction involving a key Pictet-Spengler-like annulation step has been developed, providing an efficient method for the synthesis of 3,4-dihydroquinazolines in moderate to good yields from amides, aldehydes, and amines. The multicomponent triflic anhydride mediated reaction tolerates the installation of numerous functional groups, affording extensive diversity about the heterocyclic scaffold. ...[more]

PMID: 31408069

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