Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.
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ABSTRACT:
SUBMITTER: Audemard-Verger A
PROVIDER: S-EPMC6767972 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.
Audemard-Verger Alexandra A Gasnault Jacques J Faisant Maxime M Besse Marie-Catherine MC Martin-Silva Nicolas N Berra Mado M Fournier Luc L Boutemy Jonathan J Maigne Gwenola G De Boysson Hubert H Ruet Alexis A Vabret Astrid A Chapon Françoise F Martin-Blondel Guillaume G Aouba Achille A
Open forum infectious diseases 20190930 10
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1<sup>+</sup> macrophages could be the T-cells partnership in immune exhaustion and virus escape. ...[more]
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