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Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis.

ABSTRACT: A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki-Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biaryl analogs is accomplished at room temperature using the strategy, which enhances the practical usefulness of this method.

SUBMITTER: Ji H

PROVIDER: S-EPMC6768141 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis.

Ji Hong H Cai Jianghong J Gan Nana N Wang Zhaohua Z Wu Liyang L Li Guorong G Yi Tao T

Chemistry Central journal 20181219 1

A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki-Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biary ...[more]

PMID: 30564982

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