Ontology highlight
ABSTRACT:
SUBMITTER: Yordanov TE
PROVIDER: S-EPMC6771566 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yordanov Teodor E TE Hipolito Victoria E B VEB Liebscher Gudrun G Vogel Georg F GF Stasyk Taras T Herrmann Caroline C Geley Stephan S Teis David D Botelho Roberto J RJ Hess Michael W MW Huber Lukas A LA
Traffic (Copenhagen, Denmark) 20190901 9
Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal multimeric BLOC-1-related complex (BORC) regulates the size of these organelles via PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate [PI(3,5)P<sub>2</sub> ] production. Deletion of the core BORC component Diaskedin led to increased levels of PI(3 ...[more]