Ontology highlight
ABSTRACT:
SUBMITTER: Smaligo AJ
PROVIDER: S-EPMC6942233 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191202 3
Reported herein is a one-pot protocol for the oxodealkenylative introduction of carbonyl functionalities into terpenes and terpene-derived compounds. This transformation proceeds by Criegee ozonolysis of an alkene, reductive cleavage of the resulting α-alkoxy hydroperoxide, trapping of the generated alkyl radical with 2,2,6,6-tetramethylpiperidin-1-yl (TEMPO), and subsequent oxidative fragmentation with MMPP. Using readily available starting materials from chiral pool, a variety of carbonyl-cont ...[more]