Ontology highlight
ABSTRACT:
SUBMITTER: Colon-Thillet R
PROVIDER: S-EPMC6772013 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Colón-Thillet Rossana R Hsieh Emily E Graf Laura L McLaughlin Richard N RN Young Janet M JM Kochs Georg G Emerman Michael M Malik Harmit S HS
PLoS biology 20191001 10
Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenesis of positions under positive selection in a host antiviral protein could enhance its restrictive properties. We tested approximately 700 variants of human MxA, generated by combinatorial mutagenesis, for their ability to restrict Thogotovirus (THOV ...[more]