Ontology highlight
ABSTRACT:
SUBMITTER: Ainali C
PROVIDER: S-EPMC3112093 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Ainali Chrysanthi C Simon Michelle M Freilich Shiri S Espinosa Octavio O Hazelwood Lee L Tsoka Sophia S Ouzounis Christos A CA Hancock John M JM
BMC evolutionary biology 20110525
<h4>Background</h4>Cellular ATP levels are generated by glucose-stimulated mitochondrial metabolism and determine metabolic responses, such as glucose-stimulated insulin secretion (GSIS) from the β-cells of pancreatic islets. We describe an analysis of the evolutionary processes affecting the core enzymes involved in glucose-stimulated insulin secretion in mammals. The proteins involved in this system belong to ancient enzymatic pathways: glycolysis, the TCA cycle and oxidative phosphorylation.< ...[more]