Ontology highlight
ABSTRACT:
SUBMITTER: King BF
PROVIDER: S-EPMC6772291 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
King B F BF Townsend-Nicholson A A Wildman S S SS Thomas T T Spyer K M KM Burnstock G G
The Journal of neuroscience : the official journal of the Society for Neuroscience 20000701 13
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under voltage-clamp conditions, only homomeric rP2X(2) receptors were fully functional and gave rise to large inward currents (2-3 microA) to extracellular ATP. Coexpression of rP2X(2) and rP2X(6) subunits in Xenopus oocytes resulted in a heteromeric rP2X(2/ ...[more]