Ontology highlight
ABSTRACT:
SUBMITTER: Ryu NM
PROVIDER: S-EPMC6773234 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell cycle (Georgetown, Tex.) 20190815 20
DNA repair proteins have been found to localize to the centrosomes and defects in these proteins cause centrosome abnormality. Centrobin is a centriole-associated protein that is required for centriole duplication and microtubule stability. A recent study revealed that centrobin is a candidate substrate for ATM/ATR kinases. However, whether centrobin is involved in DNA damage response (DDR) remains unexplored. Here we show that centrobin is phosphorylated after UV exposure and that the phosphory ...[more]