Ontology highlight
ABSTRACT:
SUBMITTER: Gildemeister OS
PROVIDER: S-EPMC2797266 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Gildemeister Otto S OS Sage Jay M JM Knight Kendall L KL
The Journal of biological chemistry 20090926 46
Exposure of cells to DNA-damaging agents results in a rapid increase in the formation of subnuclear complexes containing Rad51. To date, it has not been determined to what extent DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this process. We have analyzed subcellular fractions of HeLa and HCT116 cells and found a significant increase in nuclear Rad51 levels following exposure to a modest dose of ionizing radiation (2 grays). We also observed a DNA damage-induced ...[more]