Ontology highlight
ABSTRACT:
SUBMITTER: Liu XS
PROVIDER: S-EPMC3457539 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Liu X Shawn XS Song Bing B Tang Jiabin J Liu Weiyi W Kuang Shihuan S Liu Xiaoqi X
Molecular and cellular biology 20120806 19
Accurate chromosome segregation during cell division maintains genomic integrity and requires the proper establishment of kinetochore-microtubule attachment in mitosis. As a key regulator of mitosis, Polo-like kinase 1 (Plk1) is essential for this attachment process, but the molecular mechanism remains elusive. Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during mitosis. We show that Sgt1 dynamically localizes at the kinetochores, which lack microtubule attachments d ...[more]