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The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer.

ABSTRACT: microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this knowledge, potential approaches for the control of RAS oncogenic activation can be envisioned.

SUBMITTER: Roncarati R

PROVIDER: S-EPMC6777413 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer.

Roncarati Roberta R Lupini Laura L Shankaraiah Ram C RC Negrini Massimo M

Frontiers in oncology 20190927

microRNAs (miRNAs) regulate gene expression by modulating the translation of protein-coding RNAs. Their aberrant expression is involved in various human diseases, including cancer. Here, we summarize the experimental pieces of evidence that proved how dysregulated miRNA expression can lead to RAS (HRAS, KRAS, or NRAS) activation irrespective of their oncogenic mutations. These findings revealed relevant pathogenic mechanisms as well as mechanisms of resistance to target therapies. Based on this ...[more]

PMID: 31612113

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