Ontology highlight
ABSTRACT:
SUBMITTER: Binger KJ
PROVIDER: S-EPMC6778207 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Binger Katrina J KJ Neukam Martin M Tattikota Sudhir Gopal SG Qadri Fatimunnisa F Puchkov Dmytro D Willmes Diana M DM Wurmsee Sabrina S Geisberger Sabrina S Dechend Ralf R Raile Klemens K Kurth Thomas T Nguyen Genevieve G Poy Matthew N MN Solimena Michele M Muller Dominik N DN Birkenfeld Andreas L AL
Proceedings of the National Academy of Sciences of the United States of America 20190916 40
Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to deliver damaged or old granules to acidic lysosomes for intracellular degradation. However, excessive consumption of insulin granules can impair β cell function and cause diabetes. <i>Atp6ap2</i> is an essential accessory component of the vacuolar ATPase required for lysosomal degradative functions and autophagy. Here, we ...[more]