Ontology highlight
ABSTRACT:
SUBMITTER: Jang J
PROVIDER: S-EPMC6782112 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Jang Jiwon J Han Dasol D Golkaram Mahdi M Audouard Morgane M Liu Guojing G Bridges Daniel D Hellander Stefan S Chialastri Alex A Dey Siddharth S SS Petzold Linda R LR Kosik Kenneth S KS
PLoS biology 20190926 9
The link between single-cell variation and population-level fate choices lacks a mechanistic explanation despite extensive observations of gene expression and epigenetic variation among individual cells. Here, we found that single human embryonic stem cells (hESCs) have different and biased differentiation potentials toward either neuroectoderm or mesendoderm depending on their G1 lengths before the onset of differentiation. Single-cell variation in G1 length operates in a dynamic equilibrium th ...[more]