Ontology highlight
ABSTRACT:
SUBMITTER: Tang W
PROVIDER: S-EPMC6786299 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Tang Wei W Guo Ren R Shen Shi-Jun SJ Zheng Yang Y Lu Yu-Ting YT Jiang Meng-Meng MM Cui Xue X Jiang Ci-Zhong CZ Xie Xin X
Acta pharmacologica Sinica 20181012 5
Human liver or hepatocyte transplantation is limited by a severe shortage of donor organs. Direct reprogramming of other adult cells into hepatic cells may offer a solution to this problem. In a previous study, we have generated hepatocyte-like cells from mouse fibroblasts using only one transcription factor (TF) plus a chemical cocktail. Here, we show that human urine-derived epithelial-like cells (hUCs) can also be transdifferentiated into human hepatocyte-like cells (hiHeps) using one TF (Fox ...[more]