Ontology highlight
ABSTRACT:
SUBMITTER: Dong J
PROVIDER: S-EPMC6788867 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Science advances 20191011 10
The polar nature of the C═O bond commonly allows it to undergo direct attack by nucleophiles at the electrophilic carbon atom in which ketones and aldehydes act as alkyl carbocation equivalents. In contrast, transformations in which ketones and aldehydes act as alkyl radical equivalents (generated in carbonyl carbon) are unknown. Here, we describe a new catalytic activation mode that combines proton-coupled electron transfer (PCET) with spin-center shift (SCS) and enables C─H alkylation of heter ...[more]