Ontology highlight
ABSTRACT:
SUBMITTER: Riglar DT
PROVIDER: S-EPMC6789134 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Riglar David T DT Richmond David L DL Potvin-Trottier Laurent L Verdegaal Andrew A AA Naydich Alexander D AD Bakshi Somenath S Leoncini Emanuele E Lyon Lorena G LG Paulsson Johan J Silver Pamela A PA
Nature communications 20191011 1
Synthetic gene oscillators have the potential to control timed functions and periodic gene expression in engineered cells. Such oscillators have been refined in bacteria in vitro, however, these systems have lacked the robustness and precision necessary for applications in complex in vivo environments, such as the mammalian gut. Here, we demonstrate the implementation of a synthetic oscillator capable of keeping robust time in the mouse gut over periods of days. The oscillations provide a marker ...[more]