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Linkage disequilibrium maps for European and African populations constructed from whole genome sequence data.

ABSTRACT: Quantification of linkage disequilibrium (LD) patterns in the human genome is essential for genome-wide association studies, selection signature mapping and studies of recombination. Whole genome sequence (WGS) data provides optimal source data for this quantification as it is free from biases introduced by the design of array genotyping platforms. The Malécot-Morton model of LD allows the creation of a cumulative map for each choromosome, analogous to an LD form of a linkage map. Here we report LD maps generated from WGS data for a large population of European ancestry, as well as populations of Baganda, Ethiopian and Zulu ancestry. We achieve high average genetic marker densities of 2.3-4.6/kb. These maps show good agreement with prior, low resolution maps and are consistent between populations. Files are provided in BED format to allow researchers to readily utilise this resource.

SUBMITTER: Vergara-Lope A

PROVIDER: S-EPMC6797713 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Linkage disequilibrium maps for European and African populations constructed from whole genome sequence data.

Vergara-Lope Alejandra A Jabalameli M Reza MR Horscroft Clare C Ennis Sarah S Collins Andrew A Pengelly Reuben J RJ

Scientific data 20191017 1

Quantification of linkage disequilibrium (LD) patterns in the human genome is essential for genome-wide association studies, selection signature mapping and studies of recombination. Whole genome sequence (WGS) data provides optimal source data for this quantification as it is free from biases introduced by the design of array genotyping platforms. The Malécot-Morton model of LD allows the creation of a cumulative map for each choromosome, analogous to an LD form of a linkage map. Here we report ...[more]

PMID: 31624256

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