Ontology highlight
ABSTRACT:
SUBMITTER: Mazzini S
PROVIDER: S-EPMC6801708 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Mazzini Stefania S Gargallo Raimundo R Musso Loana L De Santis Francesca F Aviñó Anna A Scaglioni Leonardo L Eritja Ramon R Di Nicola Massimo M Zunino Franco F Amatulli Annabella A Dallavalle Sabrina S
International journal of molecular sciences 20191004 19
The stabilization of G-quadruplex DNA structures by small molecules with affinity to oncogene promoters has emerged as a promising anticancer strategy, due to a potential role in gene expression regulation. We explored the ability of BMH-21 (<b>1</b>) and its analogue BA-41 (<b>2</b>) to bind the G-quadruplex structure present in the c-KIT promoter by biophysical methods and molecular modeling. We provide evidence that both compounds interact with the c-KIT 21-mer sequence. The stable monomeric ...[more]