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ABSTRACT:
SUBMITTER: Kawano-Kawada M
PROVIDER: S-EPMC6803629 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Kawano-Kawada Miyuki M Manabe Kunio K Ichimura Haruka H Kimura Takumi T Harada Yuki Y Ikeda Koichi K Tanaka Shiho S Kakinuma Yoshimi Y Sekito Takayuki T
Scientific reports 20191021 1
In nutrient-rich conditions, basic amino acids are actively accumulated into the vacuoles by H<sup>+</sup>-coupled transporters in Saccharomyces cerevisiae. In addition to the H<sup>+</sup>-coupled systems, the existence of an exchanger for arginine and histidine was indicated by kinetic analysis using isolated vacuolar membrane vesicles; however, the gene(s) involved in the activity has not been identified. Here, we show that the uptake activity of arginine driven by an artificially imposed his ...[more]