Ontology highlight
ABSTRACT:
SUBMITTER: Triana-Martinez F
PROVIDER: S-EPMC6803708 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature communications 20191021 1
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification. Senescent cells present a slightly depolarized plasma membrane and higher c ...[more]