Ontology highlight
ABSTRACT:
SUBMITTER: Belasri K
PROVIDER: S-EPMC6803843 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20191004 19
By direct coupling 7-azaindole and cyclic imines, such as 3,4-dihydroisoquinoline, 6,7-dihydrothieno[3,2-<i>c</i>]pyridine, 3,4-dihydro-β-carboline, and 4,5-dihydro-<i>3H</i>-benz[<i>c</i>]azepine, new 3-substituted 7-azaindole derivatives have been synthesized. The reaction was extended to 4-azaindoles and 6-azaindoles, as electron-rich aromatic compounds. The lowest reactivity was observed in the case of C-3 substitution of 5-azaindole. In this case, the aza-Friedel-Crafts reaction took place ...[more]