Ontology highlight
ABSTRACT:
SUBMITTER: Jang JY
PROVIDER: S-EPMC6803859 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Jang Jun Young JY Kim Hyun-Jung HJ Han Byung Woo BW
Molecules (Basel, Switzerland) 20191001 19
Imatinib is an effective anticancer drug for the treatment of leukemia. Interestingly, when an FDA-approved drug library was tested for agents that block peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation at Ser245 to evaluate possibilities of antidiabetic drug repositioning, imatinib was determined as a PPARγ antagonist ligand. However, it is not well understood how imatinib binds to PPARγ or would improve insulin sensitivity without classical agonism. Here, we report the crys ...[more]