Ontology highlight
ABSTRACT:
SUBMITTER: Saphire EO
PROVIDER: S-EPMC6814399 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Saphire Erica Ollmann EO Schendel Sharon L SL Gunn Bronwyn M BM Milligan Jacob C JC Alter Galit G
Nature immunology 20181017 11
Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this deadly disease; however, the specific mechanisms of action of protective antibodies have yet to be defined. In this Perspective we discuss the antibody features that correlate with in vivo protection during infection with Ebola virus, based on the results of a systematic and comprehensive study of antibodies direct ...[more]