Association of vascular endothelial growth factor expression and polymorphisms with the risk of gestational diabetes mellitus.

ABSTRACT:

Objective

To study the associations of vascular endothelial growth factor (VEGF) expression and its gene polymorphisms with the risk of gestational diabetes mellitus (GDM).

Methods

A total of 239 GDM patients (GDM group) and 275 healthy pregnant women (Control group) were included in this study. VEGF genotypes (including rs2146323, rs2010963, rs3025039, rs3025010, and rs833069) were analyzed by TaqMan assay. ELISA was used to determine the serum VEGF levels. The software SHEsis was performed to analyze haplotypes.

Results

The carrier with the rs2146323 AA, CA+AA genotypes, and A allele, as well as the rs3025039 CT, TT, CT+TT genotypes, and T allele showed the increased risk of GDM (all P < 0.05), but the distributions of genotype and allele at rs2010963, rs3025010, an

SUBMITTER: Dong PP 

PROVIDER: S-EPMC6818619 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature