Exploration of intermediate-sized INDELs by next-generation multigene panel testing in Han Chinese patients with breast cancer.
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ABSTRACT:
SUBMITTER: Hata C
PROVIDER: S-EPMC6820797 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Exploration of intermediate-sized INDELs by next-generation multigene panel testing in Han Chinese patients with breast cancer.
Hata Chihiro C Nakaoka Hirofumi H Xiang Yu Y Wang Dong D Yang Anping A Liu Dahai D Liu Fang F Zou Qingfeng Q Zheng Ke K Inoue Ituro I You Hua H
Human genome variation 20191029
Multigene panel testing via next-generation sequencing focuses on the detection of small-sized mutations, such as single nucleotide variants and short insertions and deletions (INDELs). However, intermediate-sized INDELs have not been fully explored due to technical difficulties. Here, we performed bioinformatics analyses to identify intermediate-sized INDELs in 54 cancer-related genes from 583 Han Chinese patients with breast cancer. We detected a novel deletion-insertion in a translational var ...[more]
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