Hypomethylation of 111 Probes Predicts Poor Prognosis for Glioblastoma.
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ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC6823878 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Hypomethylation of 111 Probes Predicts Poor Prognosis for Glioblastoma.
Chen Qi Q Zhao Min M Yin Chengliang C Feng Shiyu S Hu Jian J Zhang Qiang Q Ma Xiaodong X Xue Wanguo W Shi Jinlong J
Frontiers in neuroscience 20191025
Glioblastoma (GBM) is a complicated brain tumor with heterogeneous outcome. Identification of effective biomarkers is an urgent need for the treatment decision-making and precise evaluation of prognosis. Based on a relatively large dataset of genome-wide methylation (138 glioblastoma patients), a joint-score of 111 methyl-probes was found to be of statistical significance for prognostic evaluation. Low joint-score were significantly associated with adverse outcomes (OS: <i>P</i> < 0.001, PFS: <i ...[more]
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