Ontology highlight
ABSTRACT:
SUBMITTER: Le DN
PROVIDER: S-EPMC6824594 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature chemistry 20180730 9
Molecular recognition plays a key role in enzyme-substrate specificity, the regulation of genes, and the treatment of diseases. Inspired by the power of molecular recognition in enzymatic processes, we sought to exploit its use in organic synthesis. Here we demonstrate how a synthetic rhodium-based catalyst can selectively bind a dehydroamino acid residue to initiate a sequential and stereoselective synthesis of cyclic peptides. Our combined experimental and theoretical study reveals the underpi ...[more]