Ontology highlight
ABSTRACT:
SUBMITTER: Saito N
PROVIDER: S-EPMC6826962 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Saito Norihiko N Hirai Nozomi N Aoki Kazuya K Sato Sho S Suzuki Ryo R Hiramoto Yu Y Fujita Satoshi S Nakayama Haruo H Hayashi Morito M Sakurai Takatoshi T Iwabuchi Satoshi S
Cancers 20191015 10
The Cancer Genome Atlas (TCGA) project described a robust gene expression-based molecular classification of glioblastoma (GBM), but the functional and biological significance of the subclasses has not been determined. The present comprehensive analysis of 25 glioma-initiating cell (GIC) lines classifies GIC lines into four subtypes (classical, mesenchymal, proneural, and neural) that are closely related to the TCGA GBM subclasses and display distinct lineage characteristics and differentiation b ...[more]