Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis.
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ABSTRACT:
SUBMITTER: Topfer U
PROVIDER: S-EPMC6828711 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Serpent/dGATAb regulates Laminin B1 and Laminin B2 expression during Drosophila embryogenesis.
Töpfer Uwe U Bischoff Maik C MC Bartkuhn Marek M Holz Anne A
Scientific reports 20191104 1
Transcriptional regulation of Laminin expression during embryogenesis is a key step required for proper ECM assembly. We show, that in Drosophila the Laminin B1 and Laminin B2 genes share expression patterns in mesodermal cells as well as in endodermal and ectodermal gut primordia, yolk and amnioserosa. In the absence of the GATA transcription factor Serpent, the spatial extend of Laminin reporter gene expression was strongly limited, indicating that Laminin expression in many tissues depends on ...[more]
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