Structural topology defines protective CD8+ T cell epitopes in the HIV proteome.
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ABSTRACT:
SUBMITTER: Gaiha GD
PROVIDER: S-EPMC6855781 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Structural topology defines protective CD8<sup>+</sup> T cell epitopes in the HIV proteome.
Gaiha Gaurav D GD Rossin Elizabeth J EJ Urbach Jonathan J Landeros Christian C Collins David R DR Nwonu Chioma C Muzhingi Itai I Anahtar Melis N MN Waring Olivia M OM Piechocka-Trocha Alicja A Waring Michael M Worrall Daniel P DP Ghebremichael Musie S MS Newman Ruchi M RM Power Karen A KA Allen Todd M TM Chodosh James J Walker Bruce D BD
Science (New York, N.Y.) 20190501 6439
Mutationally constrained epitopes of variable pathogens represent promising targets for vaccine design but are not reliably identified by sequence conservation. In this study, we employed structure-based network analysis, which applies network theory to HIV protein structure data to quantitate the topological importance of individual amino acid residues. Mutation of residues at important network positions disproportionately impaired viral replication and occurred with high frequency in epitopes ...[more]
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