Ontology highlight
ABSTRACT:
SUBMITTER: Choi BD
PROVIDER: S-EPMC6857271 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Journal for immunotherapy of cancer 20191114 1
Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfunction and exhaustion. One mechanism by which gliomas and other cancers can hamper CAR T cells is through surface expression of inhibitory ligands such as programmed cell death ligand 1 (PD-L1). Using the CRIPSR-Cas9 system, we created universal CAR T cells re ...[more]