Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths' Daily Lives.
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ABSTRACT:
SUBMITTER: Miranda R
PROVIDER: S-EPMC6857838 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths' Daily Lives.
Miranda Robert R Wemm Stephanie E SE Treloar Padovano Hayley H Carpenter Ryan W RW Emery Noah N NN Gray Joshua C JC Mereish Ethan H EH
Clinical psychological science : a journal of the Association for Psychological Science 20190501 5
Theories of addiction posit that stimuli associated with drug use, including both exteroceptive (e.g., paraphernalia) and interoceptive (e.g., feeling tense or "stressed"), evoke craving and contribute to the pathogenesis of substance misuse. Control over drug cue response and stress is essential for moderating use. Building from laboratory data supporting associations between cue exposure, stress, and craving, this study tested whether these associations generalize to real-world settings and ex ...[more]
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Project description:Low levels of distress tolerance have been identified as an important vulnerability factor for negative cannabis outcomes. The current study is the first known experimental manipulation of state distress to test whether distress tolerance interacts with state distress to predict the urge to use cannabis. Current cannabis users (N = 126; 88.9% with cannabis use disorder; 54.0% non-Hispanic Caucasian) were randomly assigned to a distress task condition or neutral (reading) task condition. Participants in the 2 conditions did not differ on distress tolerance, negative affect (NA), or craving at baseline. The distress tolerance × condition interaction significantly predicted task NA, such that low (but not high) distress tolerance was related to greater state NA throughout the task. The distress tolerance × condition interaction significantly predicted cannabis craving during the task, such that the distress condition was related to greater cannabis craving at lower (but not higher) levels of distress tolerance. In the distress condition, those who endorsed coping motives during the task reported lower distress tolerance. Together these findings suggest that individuals with lower distress tolerance experienced greater NA during a laboratory-induced distress and reported greater cannabis craving when NA was greatest during the task. This experimental study adds to a growing, but limited, literature implicating lower levels of distress tolerance to the maintenance and relapse of cannabis use. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Project description:BackgroundSimulations in healthcare reproduce clinical situations in stressful conditions. Repeated stress exposure might influence the learning process in simulation as well as real-life.Objectives1) To record heart rate and heart rate variability evolution during one-day simulation over one year; 2) To analyze the effect of repetitive high-fidelity simulations on the risk of post-traumatic stress disorder.Study designSingle-center, investigator-initiated RCT. 48 participants were randomized in 12 multidisciplinary teams of French Emergency Medical Services to manage infant shock in high-fidelity simulations. In the experimental group, 6 multidisciplinary teams were exposed to 9 different simulation sessions over 1 year. In the control group, 6 multidisciplinary teams participated in only 3 simulation sessions, in common with those of the experimental group (initial, intermediate after 6 months, and finally after 1 year). Heart rate (HR) and heart rate variability (HRV) were analyzed on a 24-hour Holter from the day prior to simulation until the end of simulation. Questionnaires of Impact of Event Scale-Revised at 7 days and Post-traumatic Check-List Scale at 1 month were used to detect possible post-traumatic stress disorder in participants. p<0.05 was considered significant.ResultsStress increased during each simulation in the two groups. After analysis on the 24-hour period, there was no significant difference between the two groups during the initial simulation session in terms of heart rate and heart rate variability. In the 24-hour period of the intermediate and final simulation sessions, the level of stress was higher in the control group during the diurnal (p = 0.04) and nocturnal periods (p = 0.01). No participant developed post-traumatic stress disorder after the 72 simulation sessions.ConclusionsDespite the stress generated by simulation, the more the sessions were repeated, the less were their repercussions on the daily lives of participants, reflected by a lower sympathetic activity. Moreover, repetition of simulations did not lead to post-traumatic stress disorder.Trial registrationClinicalTrials.gov NCT02424890.
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