Ontology highlight
ABSTRACT:
SUBMITTER: Webber BR
PROVIDER: S-EPMC6864045 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Webber Beau R BR Lonetree Cara-Lin CL Kluesner Mitchell G MG Johnson Matthew J MJ Pomeroy Emily J EJ Diers Miechaleen D MD Lahr Walker S WS Draper Garrett M GM Slipek Nicholas J NJ Smeester Branden A BA Lovendahl Klaus N KN McElroy Amber N AN Gordon Wendy R WR Osborn Mark J MJ Moriarity Branden S BS
Nature communications 20191119 1
The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with unintended genomic alterations and genotoxicity. Here, we apply base editor technology for multiplex gene modification in primary human T cells in support of an allogeneic CAR-T platform a ...[more]