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Disorder-Specific Alteration in White Matter Structural Property in Adults With Autism Spectrum Disorder Relative to Adults With ADHD and Adult Controls.


ABSTRACT: OBJECTIVE:Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are not only often comorbid but also overlapped in behavioral and cognitive abnormalities. Little is known about whether these shared phenotypes are based on common or different underlying neuropathologies. Therefore, this study aims to examine the disorder-specific alterations in white matter (WM) structural property. METHOD:The three comparison groups included 23 male adults with ASD (21.4?±?3.1 years), 32 male adults with ADHD (23.4?±?3.3 years), and 29 age-matched healthy male controls (22.4?±?3.3 years). After acquisition of the diffusion spectrum imaging (DSI), whole brain tractography was reconstructed by a tract-based automatic analysis. Generalized fractional anisotropy (GFA) values were computed to indicate tract-specific WM property with adjusted P value?

SUBMITTER: Chiang HL 

PROVIDER: S-EPMC6866870 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Disorder-Specific Alteration in White Matter Structural Property in Adults With Autism Spectrum Disorder Relative to Adults With ADHD and Adult Controls.

Chiang Huey-Ling HL   Chen Yu-Jen YJ   Lin Hsiang-Yuan HY   Tseng Wen-Yih Isaac WI   Gau Susan Shur-Fen SS  

Human brain mapping 20160915 1


<h4>Objective</h4>Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are not only often comorbid but also overlapped in behavioral and cognitive abnormalities. Little is known about whether these shared phenotypes are based on common or different underlying neuropathologies. Therefore, this study aims to examine the disorder-specific alterations in white matter (WM) structural property.<h4>Method</h4>The three comparison groups included 23 male adults with ASD (21  ...[more]

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