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L-Serine Lowers the Inflammatory Responses during Pasteurella multocida Infection.

ABSTRACT: Pasteurella multocida causes a variety of infectious diseases in various species of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of host-pathogen interaction is unclear. Here, we found that l-serine levels were significantly decreased in murine lungs infected with P. multocida Exogenous l-serine supplementation significantly increased the survival rate of mice and decreased the colonization of P. multocida in the lungs of mice. Notably, l-serine decreased the macrophage- and neutrophil-mediated inflammatory responses in mice during P. multocida infection.

SUBMITTER: He F

PROVIDER: S-EPMC6867830 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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l-Serine Lowers the Inflammatory Responses during Pasteurella multocida Infection.

He Fang F Yin Zheng Z Wu Chenlu C Xia Yaoyao Y Wu Miaomiao M Li Pan P Zhang Huihui H Yin Yuanyuan Y Li Nengzhang N Zhu Guoqiang G Ren Wenkai W Peng Yuanyi Y

Infection and immunity 20191118 12

Pasteurella multocida causes a variety of infectious diseases in various species of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of host-pathogen interaction is unclear. Here, we found that l-serine levels were significantly decreased in murine lungs infected with P. multocida Exogenous l-serine supplementation significantly increased the survival rate of mice and decreased the colonization of P. mult ...[more]

PMID: 31570555

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